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Unveiling Cannabidivarin (CBDV): The Unsung Hero That Has Vast Potential

Exploring the Depths of a Lesser-Known Cannabinoid

In the vast and intricate world of cannabis, a multitude of cannabinoids lie hidden, awaiting exploration and understanding. Among these is Cannabidivarin, or CBDV, a compound often overshadowed by its more famous counterparts. As a cannabinoid researcher, I find it crucial to shed light on these lesser-discussed constituents of the cannabis plant, for each holds a unique key to potential therapeutic benefits.

CBDV: A Close Relative of CBD with a Distinctive Twist

CBDV, a homolog of CBD, shares a strikingly similar structure with its well-known sibling. This relationship is evident in their molecular composition, where CBDV has 7 double bond isomers and 30 stereoisomers, similar to CBD. However, CBDV's unique characteristic lies in its side-chain, which is shorter by two methylene bridges. For the layperson, this means that CBDV, like CBD, is a non-intoxicating component of the cannabis plant, causing no euphoric response in patients.

The Pioneering Discovery and Potential of CBDV

Discovered nearly half a century ago, CBDV has long been a subject of interest in cannabinoid research. The pharmaceutical giant GW Pharma, known for bringing CBD into the limelight, has delved deep into the potential of CBDV. They've been developing a CBDV-based drug, GPW2006, aimed at reducing or preventing epileptic and other forms of seizures.

Controversy and Progress: The Path of CBDV in Medicine

GW Pharma's journey with CBDV has not been without its hurdles.

Their initial foray into CBD-based pharmaceuticals met with mixed responses, necessitating further research.

Their perseverance has led to promising findings, indicating CBDV's influence on neurochemical pathways related to capsaicin receptors, crucial in managing various types of epileptic seizures.

Groundbreaking Studies: CBDV's Expanding Therapeutic Horizon

A landmark study in 2018 by the Center for Behavioral Sciences and Mental Health in Rome highlighted CBDV's potential in addressing neurobehavioral issues associated with Rett syndrome, a devastating condition predominantly affecting young girls.

The study showed CBDV's efficacy in both genetically and chemically induced models of the disease. This was complemented by the 2019 findings in the Journal of Psychopharmacology and the British Journal of Pharmacology, demonstrating CBDV's remarkable ability to improve memory deficits and muscle tone in conditions like Muscular Dystrophy.

CBDV and Autism: A New Frontier

The potential of CBDV extends to addressing conditions like autism, with GW Pharmaceuticals gearing up for new phase trials and studies. Additionally, CBDV's anti-nausea properties have been spotlighted, offering a beacon of hope for creating plant-based medicines for cancer patients and beyond.

CBDV in the Cannabis Ecosystem

With well over 100 cannabinoids identified in the cannabis plant, CBDV stands out for its ability to relieve convulsions and nausea. It's a fascinating element that we're just beginning to understand as cannabis science matures. While CBDV is present in only trace amounts in many CBD products, its presence is pivotal.

The Future of Cannabinoid Medicine: Patient-Led, Science-Supported

The unfolding story of CBDV in cannabinoid medicine is a testament to the power of patient experiences leading the way. Anecdotal cases and their studies are vital in sparking the interest that fuels scientific inquiry and evidence-based discoveries.

In conclusion, CBDV exemplifies the richness and complexity of the cannabis plant.

As a researcher, I am exhilarated by the opportunity to unravel the mysteries of cannabinoids like CBDV, guided by the experiences of patients and supported by scientific rigor. The journey of understanding and harnessing the full potential of cannabis is ongoing, and compounds like CBDV are at the forefront of this exciting exploration.

The concept of balancing the Endocannabinoid System (ECS) is a sophisticated and multi-faceted approach, particularly when considering the inclusion of various exogenous plant constituents like CBDV. Such compounds are integral to an ongoing protocol aimed at achieving equilibrium within the ECS. Other cannabinoids, such as CBE and CBT, also play a critical role in this process.

They are key in activating and maintaining the balance of the ECS, primarily due to their pivotal interactions with endocannabinoids like OEA (Oleoylethanolamide) and AEA (Anandamide).

This interaction between exogenous cannabinoids from plants and endogenous cannabinoids produced within the body creates what is known as an exo/endo synergy. This synergy is crucial for the effective functioning of the ECS, influencing various physiological processes and potentially contributing to improved health outcomes.

This concept underscores the importance of a comprehensive understanding of both plant-derived and endogenous cannabinoids in the pursuit of optimal ECS balance.


Pretzsch CM, Voinescu B, Lythgoe D, Horder J, Mendez MA, Wichers R, Ajram L, Ivin G, Heasman M, Edden RAE, Williams S, Murphy DGM, Daly E, McAlonan GM. Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy. Transl Psychiatry. 2019 Nov 20;9(1):313. doi: 10.1038/s41398-019-0654-8. PMID: 31748505; PMCID: PMC6868232

Vigli D, Cosentino L, Raggi C, Laviola G, Woolley-Roberts M, De Filippis B. Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome. Neuropharmacology. 2018 Sep 15;140:121-129. doi: 10.1016/j.neuropharm.2018.07.029. Epub 2018 Jul 27. PMID: 30056123

Libzon S, Schleider LB-L, Saban N, et al. Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders. Journal of Child Neurology. 2018;33(9):565-571. doi:10.1177/0883073818773028


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